Open your audio settings and set your sound configuration to 2. In the dialog that appears, check “Automatically fix file system errors” and “Scan for and attempt recovery of bad sectors. Disable any mods added and start a "new" save to see if the issue occurs on a brand new game. If it does not crash on a new game, the issue most likely is related to a bad save and/or mod. Fallout 4 CTD (crash on desktop) Fallout 4 Crash on Xbox One: This case is different from the above three cases.
Modders are welcome to use this mod as a framework or create mods depending on it. You should check the settings below: 1) Check your computer resolution and the resolution set in your Fallout 4, and make sure the both resolution is the same. The download link will look like this: After you've downloaded the mod manager, extract the contents and place the Fallout 4 Mod Manager folder into your Fallout 4 directory. Many mods have been created to solve the crashing issue in Fallout New Vegas.
If you receive this sort of Fallout 4 crashing, try restarting the game, powering cycle the console, disabling mods How to fix Fallout 4 Game Crashes on Startup Fallout 4 has, for 10 months, refused to start up.